biochemical and biological substances for medical diagnostics and analysis, namely, detection of anti-PEG antibodies, anti-POEGMA antibodies, other immunogenic responses that hinder a therapeutic intervention, and companion diagnostics; pharmaceutical and veterinary preparations for medical purposes, including contrast agents and contrast media used in medical imaging such as contrast media used for X-ray, MRI, or ultrasound imaging; Therapeutic peptides, proteins, small molecules, antibodies, polypeptides, drug-conjugates, lipid nanoparticles, aptamers, liposomes, microparticles, micelles, and polymers for the purpose of providing therapeutic intervention with altered pharmacokinetics and reduced immunogenicity; pharmaceutical preparations and substances for the treatment of gout, solid and liquid tumors, autoimmune disease, metabolic disorders, cardiovascular disease, infectious disease, and other disorders and diseases treatable with enzyme replacement therapy