Platform and process for point-of-care real-time cash price comparison of prescription medications providing the lowest cost pharmacies and mail order facilities, which is integrated directly into Electronic Medical Records (EMR) systems and within the e-Prescribing workflow to be accessible to health care providers and the patient during and within the Patient/health care provider encounter and in advance of the transmission of the prescription to the selected and designated pharmacies; Platform and process which provides alternative drug options to payor's and insurers including health care plans, self-insured employers, pharmacy benefit managers, health insurance carriers, and other stakeholders, which is integrated directly into Electronic Medical Records (EMR) systems and seeks and recommends in real-time alternative and clinically/therapeutically equivalent and applicable drug therapies at the lowest cost; Platform and process for the delivery of real-time prescription fill, re-fill, and abandoned prescription claim data to the Electronic Medical Record (EMR) system, health care provider, plan, self-insured employer, pharmacy benefit manager or health insurance carrier, and alerts the health care provider or prescriber of any abnormalities in drug therapy adherence and compliance