Medical devices, namely, catheters, in particular, laser catheters, laser ablation catheters, aspiration catheters, deflecting tip catheters, rapid exchange catheters, laser catheters featuring mechanical cutters, and laser catheters including a mechanical blade; aspiration devices, namely, aspiration tubing, filters, suction pumps, containers, and suction cannulas; laser systems, comprising, laser pumps, solid state lasers, and laser ablation systems with aspiration, laser ablation systems with photo-acoustical feedback sensing, and laser ablation systems with sensors to detect specific tissue types; laser systems, featuring, laser ablation systems, laser ablation catheters, laser catheters, aspiration catheters, aspiration tubing, and mechanical cutters, for medical uses, namely, the treatment of stenosis, artery stenosis, in-stent restenosis, restenosis and other occlusions, atherectomy, angioplasty, laser angioplasty procedures, peripheral interventional procedures, cardiac interventional procedures and other interventional procedures, including, the removal of cardiac leads, the removal of pacemaker leads, crossing total occlusions (CTO), treatment of peripheral artery disease (PAD), treatment of coronary artery disease (CAD), the removal of thrombus, treatment for thrombectomy, treatment of tumor ablations, treatment of barrett's disease, treatment of esophageal diseases, and treatment of stomach and intestinal growths; lasers for medical and surgical use for use with operating software and a graphical user interface; balloons, guidewires, and sheaths for the use in peripheral interventional procedures, cardiac interventional procedures and other interventional procedures; Medical device systems for aspiration of unwanted arterial and/or venous intravascular material, namely, medical devices to monitor, sense, record, control, and/or adjust sensors, valves, catheters, pumps, or vacuum sources for aspiration; medical device systems also comprising computer hardware and software for use with medical devices, namely, to monitor, sense, record, control, and/or adjust sensors, valves, catheters, pumps, or vacuum sources for aspiration