Research and development of electron paramagnetic resonance based oxygen imaging instruments for medical purposes that provide three-dimensional oxygen images in live tissues and biomaterials specifically adapted for oxygen mapping in cancer imaging, hypoxia mapping, cancer treatment, tissue engineering, cell based therapies, regenerative medicine, artificial organs, in vitro oxygen mapping of artificial tissue grafts and organs, and in vivo tissue graft assessment in animals and in humans. Biotechnology research; Development of new technology for others in the field of biotechnology; Research and development in the field of biotechnology; Research and Development in the field of medical imaging; Research, development and synthesis of radicals for physiologic imaging