Diagnostic biomarker reagents for medical and clinical purposes; biomarkers for use individually or in combination to detect tissue formation, tissue remodeling, or tissue destruction; biomarker assays to identify disease activity; biomarker assays to quantify disease activity; biomarker assays to analyse disease activity; diagnostic kits comprised of medical diagnostic reagents and assays for use in disease detection, disease analysis and quantifying disease activity; medical diagnostic agents; medical diagnostic reagents; clinical diagnostic agents; clinical diagnostic reagents; diagnostic preparations, substances and materials; medical diagnostic test strips; diagnostic preparations for medical purposes; diagnostic agents for medical use.

Design and development of blood-based biomarker assays to identify, quantify and analyse disease activity; design and development of diagnostic biomarker reagents for medical, pharmaceutical, and scientific purposes; design and development of biochemical, pharmaceutical, and medical assays; design and development of biomarkers for use individually or in combination to detect tissue formation, tissue remodeling, or tissue destruction; scientific and pharmaceutical research in the field of biomarkers and biomarker discovery; identification of predictive and prognostic biomarkers for clinical trials; identifing patients for clinical trials most likely to respond to a given treatment using biomarkers; laboratory services relating to clinical trials; clinical trials; analysis of pharmacodynamic data; analysis of data relating to biomarkers; development of diagnostic preparations, equipment and tests; clinical testing services; diagnostic testing services; testing services relating to the detection and measurement of biomarkers; testing samples for the presence of biomarkers; laboratory services; medical laboratory services; research laboratory services; medical, pre-clinical, clinical, biological, biotechnological and pharmaceutical research, experimentation, development, and analysis; advice, information and assistance relating to the foregoing.