Genetically engineered animal cells for in vitro production for medical or veterinary use of biological active recombinant proteins or genetically engineered derivatives thereof using co-expression of a gene encoding a proprotein or precursor protein and a gene encoding a proprotein convertase, including genetically engineered animals for in vivo production for medical or veterinary use of biologically active recombinant proteins or genetically engineered derivatives thereof using co-expression of a gene encoding a proprotein or precursor protein and a gene encoding a proprotein convertase, test-tube manufacture for medical or veterinary use of biologically active recombinant proteins genetically engineered derivatives thereof from a proprotein or precursor protein using a proprotein convertase, biologically active recombinant proteins or genetically engineered derivatives of plasma proteins such as blood clotting factors and albumin, biological active recombinant proteins or genetically engineered derivatives of brain proteins such as neuropeptides, polypeptide hormones and receptors, biologically active recombinant proteins or genetically engineered derivatives of growth and differentiation factors such as for instance members of the TGF- BETA/BMP superfamily, biologically active recombinant proteins or genetically engineered derivatives of growth factor receptors such as the type I insulin-like growth factor receptor, biologically active recombinant proteins or genetically engineered derivatives of viral proteins from viruses, such as for example HIV, Ebola virus, Marburg virus, influenza virus, biologically active recombinant protein or genetically engineered derivatives of toxins e.g. anthrax toxin, biologically active recombinant proteins or genetically engineered derivatives of a variety of enzymes such as metalloproteinases and proprotein convertases, biologically active recombinant proteins or genetically engineered derivatives of several cell-surface receptors, adhesion molecules, signaling proteins and extracelluar-martix proteins, biologically active recombinant proteins or genetically engineered derivatives of proteins or fragments thereof for production of vaccines, biological active recombinant proteins or genetically engineered derivatives of any natural occurring of artificially designed proprotein or precursor protein which requires the action of a proprotein convertase for cleavage into biologically active components

biological , chemical, and enzyme preparations for medical and veterinary purposes, namely pharmaceutical preparations used in the treatment of mammals with enzyme insufficiency or deficiency; chemical reagents for medical and veterinary use, namely, clinical medical reagents; medical diagnostic reagents; medicines for human and veterinary purposes, namely, pharmaceutical preparations used in the treatment of mammals with enzyme insufficiency or deficiency

Biological research, namely biomedical research, biochemical research, genetic research, animal cell biotechnology research, agricultural research, and viral research; blood bank services; research and development of new pharmaceutical and research products for others; Professional consultancy, namely, technical consultation in the field of biomedical research, biochemical research, genetic research, animal cell biotechnology research, agricultural research and viral research