OptimumGeneTM is a gene design system. It implements gene optimization technology that alters both naturally occurring and recombinant gene sequences by comprehensively optimizing factors critical to transcription, translation, and co-translational protein folding to achieve the highest possible levels of productivity in any given expression system. Its algorithm takes into consideration of a variety of critical factors involved in different stages of protein expression, such as codon adaptability, mRNA structure, and various cis-elements in transcription and translation