Medical imaging, navigation, and localization/orientation apparatus and instruments consisting of miniature sensors working in conjunction with a medical positioning system and 2D or 3D medical imaging for use in association with minimal invasive surgery, diagnostic and therapeutics tools or devices, namely, guide wires, [ cardiac pacing wires, cardiac rhythm management wires, cardiac imaging wires, ] catheters, [ medical endoscopes, ] needles for medical use, [ imaging catheters, ] and cardiac pacing leads, [ percutaneous leads, pacemaker leads, ICD and defibrillator leads, medical electrodes, stents, artificial cardiac valves, vascular closure devices and cardiac closure devices ]