Pharmaceuticals preparations for regenerating human tissues and organs, for blocking or promoting vessel development, and for treatment of human disease where the treatment involves generation of, interference with or effects upon one or more signaling molecules; pharmaceutical preparations in the nature of biologicals for regenerating human tissues and organs, for blocking or promoting vessel development, and for treatment of human disease where the treatment involves generation of interference with or effects upon one or more signaling molecules; and pharmaceutical preparations in the nature of genetic therapies for regenerating human tissues and organs, for blocking or promoting vessel development, and for treatment of human disease where the treatment involves generation of, interference with or effects upon one or more signaling molecules; oral contraceptives; spermicides; tests and assays composed primarily of mammalian cells, ion channels, signaling molecules, dedifferentiated or dedifferentiating cells, and cellular contractile organizational structures for identifying molecules that can induce desirable cardiovascular, reproductive, genitourinary, gastrointestinal, infectious, hematologic, oncologic, metabolic, neurologic, pulmonary, immunologic, renal, rheumatologic, dermatologic or vision results; and tests and assays composed primarily of mammalian cells, ion channels, signaling molecules, dedifferentiated or dedifferentiating cells, and cellular contractile organizational structures for identifying a risk of cardiovascular, reproductive, genitourinary, gastrointestinal, infectious, hematologic, oncologic, metabolic, neurologic, pulmonary, immunologic, renal, rheumatologic, dermatologic and vision diseases