PROVIDING ACCESS TO AND SUPPLYING OTHERS WITH TECHNOLOGIES AND GENE SURVEY RESEARCH ENABLING THE LARGE-SCALE DETECTION, IDENTIFICATION AND COMPILATION OF GENETIC SEQUENCE POLYMORPHISMS, INCLUDING THE DEFINITION OF POPULATION FREQUENCIES; THE DETECTION, IDENTIFICATION, CHARACTERIZATION AND THE DEFINITION OF RELATIVE FREQUENCIES OF STRUCTURAL DIFFERENCES WITHIN EXPRESSED SEQUENCES, SUCH AS MUTATIONS AND ALTERNATIVE SPLICING EVENTS, DATA BASES AND EXPRESSION DATA MANAGEMENT FOR FUNCTIONAL MODELLING AND INTEGRATIVE CHARACTERIZATION OF CELLULAR PROCESSES FOR APPLICATIONS IN THE FIELDS OF BIO-ENGINEERING, DIAGNOSTICS, PROGNOSIS, THERAPEUTIC MONITORING AND DRUG DISCOVERY